Semaglutide Versus Mounjaro

woman injecting semaglutide weight loss in tampa into stomach fat


Semaglutide and Mounjaro are both medications that are used to manage type 2 diabetes. However, they belong to different classes of drugs and work in different ways. In this excerpt, we will compare and contrast the two medications.


Semaglutide is a once-weekly injectable medication that was approved by the FDA in 2017. It is a GLP-1 receptor agonist and works by mimicking the effects of a hormone called glucagon-like peptide-1 (GLP-1). This hormone stimulates insulin secretion and reduces the production of glucose in the liver. Semaglutide has been shown to significantly reduce A1C levels and lead to weight loss in people with type 2 diabetes.

Semaglutide is typically injected once a week, either by the patient or a healthcare professional. At Invigorate Wellness, all of our check ins are virtual, so the patient will be completing their own injections either by themself or with the help of a family member or friend. Our package has everything you need to self inject and is injected subcutaneously (under the skin) in the abdomen, thigh, or upper arm. 

In addition to reducing diabetic patients A1C levels, Semaglutide has also been proven very effective in achieving weight loss in patients that may or may not be diabetic. Some common side effects of semaglutide include nausea, vomiting, and diarrhea. In rare cases, it can also cause inflammation of the pancreas (pancreatitis), which can be a serious condition but is not seen often. 


Mounjaro is a once-daily oral medication that was approved by the FDA in 2020. It belongs to a class of drugs called sodium-glucose cotransporter-2 (SGLT2) inhibitors. These drugs work by blocking the reabsorption of glucose in the kidneys, which leads to increased glucose excretion in the urine. Mounjaro has been shown to significantly reduce A1C levels and promote weight loss in people with type 2 diabetes.

Mounjaro is taken once a day, with or without food. It comes in a tablet form and is taken by mouth. Some common side effects of Mounjaro include urinary tract infections, genital infections, and increased urination. In rare cases, it can also cause ketoacidosis, a serious condition that can lead to coma or death.

photo of a vial of semaglutide
Woman injecting semaglutide into her stomach fat

Which is better: Semaglutide or Mounjaro?

So, which medication is better – semaglutide or Mounjaro? The answer is not straightforward and will depend on various factors, including the individual’s medical history, lifestyle, and preferences.


One advantage of semaglutide is that it may be more effective in stubborn weight loss as well as reducing A1C levels compared to Mounjaro. Some studies have shown that semaglutide can lead to reductions of up to 1.5 percentage points, compared to up to 1.1 percentage points with Mounjaro.

However, this difference may not be clinically significant for all individuals. This may be an important consideration for individuals who are overweight or obese and are looking to manage their diabetes and lose weight at the same time.

On the other hand, Mounjaro is an oral medication and does not require injections, which may be more convenient for some people. Mounjaro also has a lower risk of causing pancreatitis compared to semaglutide.

In terms of side effects, both medications can cause gastrointestinal issues, such as nausea and diarrhea.

However, Mounjaro is associated with an increased risk of urinary tract and genital infections, while semaglutide has limited and less severe side effects. 

In conclusion, Semaglutide and Monjouro are similar but not exact. They both have benefits and side effects. When choosing which medication to go with it is important to take into consideration what you personally need.

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